Different opioid mechanisms are involved in the modulation of ACTH and gonadotrophin release in man.

Journal article

Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising hormone (LH), follicle-stimulating hormone (FSH) and plasma cortisol was therefore investigated in ten normal subjects. In the male subjects, naloxone at a dose of 25 micrograms/kg c...

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Authors: Grossman, A; Moult, P; Cunnah, D; Besser, M

• Publication status: Published
• Journal: Neuroendocrinology
• Volume: 42
• Issue: 4
• Pages: 357-360
• Publication date: 1986-01-01
• DOI: 10.1159/000124463
• EISSN: 1423-0194
• ISSN: 0028-3835
• Language: English
• Keywords: Gonadotropins, Pituitary; Adrenocorticotropic Hormone; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Hydrocortisone; Naloxone; Humans; Adult; Female; Male; Receptors, Opioid; Pituitary Gland, Anterior