Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.

Journal article

Induction of T-helper cells and T-B cell interaction have been considered to critically depend upon recognition of major histocompatibility complex (MHC) class II molecules by the T cell receptor. Mice lacking either MHC class II molecules (class II(0/0) mice) or its associated invariant chain (Ii0/0 mice) provide new opportunities to test this premise. Immune responses to some protein antigens have been studied in these mice; little is known about their ability to withstand viral infections....

Expand abstract

Authors: Battegay, M; Bachmann, M; Burhkart, C; Viville, S; Benoist, C

• Publication status: Published
• Journal: Cellular immunology
• Volume: 167
• Issue: 1
• Pages: 115-121
• Publication date: 1996-01-01
• DOI: 10.1006/cimm.1996.0014
• EISSN: 1090-2163
• ISSN: 0008-8749
• Language: English
• Keywords: T-Lymphocytes, Cytotoxic; Antibodies, Viral; Animals; Antigen-Presenting Cells; Capsid; Mice, Inbred C57BL; Histocompatibility Antigens Class II; Antigens, Differentiation, B-Lymphocyte; Mice; Viral Core Proteins; Viral Envelope Proteins; Membrane Glycoproteins