A human suppressor T cell clone which recognizes an autologous helper T cell clone.

Journal article

In contrast to the many reports of IL-2 dependent proliferating, helper or killer cell clones, there is only a single report of an IL-2 dependent suppressor cell clone, in the mouse. However by the same cloning procedures used to generate human helper cells, suppressor cell clones to influenza virus could not be generated, and so another strategy was used. Jerne's network hypothesis proposes that immune regulation results from lymphoid cell receptors recognizing determinants on other lymphoid...

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Authors: Lamb, JR; Fledmann, M

• Journal: Nature
• Volume: 300
• Issue: 5891
• Pages: 456-458
• Publication date: 1982-12-01
• DOI: 10.1038/300456a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Clone Cells; Cell Division; T-Lymphocytes, Helper-Inducer; Humans; Cell Communication; T-Lymphocytes, Regulatory; Receptors, Antigen, T-Cell