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Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.

Abstract:

Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) has been implicated in the regulation of metabolic activity in cancer and immune cells, and affects whole-body metabolism by regulating ghrelinsignalling in the hypothalamus. This has led to efforts to develop specific CaMKK2 inhibitors, and STO- 609 is the standardly used CaMKK2 inhibitor to date. We have developed a novel fluorescence-based assay by exploiting the intrinsic fluorescence properties of STO-609. Here, we report an in vit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbrc.2016.05.045

Authors


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Role:
Author
ORCID:
0000-0002-7249-4762
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Name:
Belfast-Manchester Movember Centre of Excellence
Publisher:
Elsevier
Journal:
Biochemical and Biophysical Research Communications More from this journal
Volume:
476
Issue:
2
Pages:
102-107
Publication date:
2016-05-01
Acceptance date:
2016-05-09
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Pmid:
27178209

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