Journal article
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
- Abstract:
-
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KR WIILGLNK). Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly. We have detected a R264K mutation in four patients carrying HLA-B27. In three of these patients the mutation occurred late, coinciding...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- JOURNAL OF EXPERIMENTAL MEDICINE
- Volume:
- 193
- Issue:
- 3
- Pages:
- 375-385
- Publication date:
- 2001-02-05
- DOI:
- ISSN:
-
0022-1007
- Source identifiers:
-
21702
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:21702
- UUID:
-
uuid:6d2cf00a-a31f-4ddf-b988-fa0d4a8a6f84
- Local pid:
- pubs:21702
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2001
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