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Journal article

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses

Abstract:

The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KR WIILGLNK). Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly. We have detected a R264K mutation in four patients carrying HLA-B27. In three of these patients the mutation occurred late, coinciding...

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Publication status:
Published

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Publisher copy:
10.1084/jem.193.3.375

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Journal:
JOURNAL OF EXPERIMENTAL MEDICINE
Volume:
193
Issue:
3
Pages:
375-385
Publication date:
2001-02-05
DOI:
ISSN:
0022-1007
Source identifiers:
21702
Language:
English
Keywords:
Pubs id:
pubs:21702
UUID:
uuid:6d2cf00a-a31f-4ddf-b988-fa0d4a8a6f84
Local pid:
pubs:21702
Deposit date:
2012-12-19

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