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Journal article

Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)

Abstract:
Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bmcl.2019.01.008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0002-7517-5732
Publisher:
Elsevier
Journal:
Bioorganic and Medicinal Chemistry Letters More from this journal
Volume:
29
Issue:
5
Pages:
724-728
Publication date:
2019-01-11
Acceptance date:
2019-01-09
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:1079850
UUID:
uuid:6d2bf33c-a2fb-4f76-a5bd-00a96ee55d47
Local pid:
pubs:1079850
Source identifiers:
1079850
Deposit date:
2019-12-26

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