Journal article
Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)
- Abstract:
- Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Bioorganic and Medicinal Chemistry Letters Journal website
- Volume:
- 29
- Issue:
- 5
- Pages:
- 724-728
- Publication date:
- 2019-01-11
- Acceptance date:
- 2019-01-09
- DOI:
- EISSN:
-
1464-3405
- ISSN:
-
0960-894X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1079850
- UUID:
-
uuid:6d2bf33c-a2fb-4f76-a5bd-00a96ee55d47
- Local pid:
- pubs:1079850
- Source identifiers:
-
1079850
- Deposit date:
- 2019-12-26
Terms of use
- Copyright holder:
- Magri, A et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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