Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study.

Journal article

Silent brain infarcts and white matter lesions are frequently seen on magnetic resonance imaging in healthy elderly people and both are associated with an increased risk of stroke and dementia. Plasma total homocysteine may be a potentially modifiable risk factor for stroke and dementia. We examined whether elevated total homocysteine levels are associated with silent brain infarcts and white matter lesions. The Rotterdam Scan Study is a population-based study of 1,077 people aged 60 to 90 ye...

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Authors: Vermeer, SE; van Dijk, E; Koudstaal, P; Oudkerk, M; Hofman, A

• Publication status: Published
• Journal: Annals of neurology
• Volume: 51
• Issue: 3
• Pages: 285-289
• Publication date: 2002-03-01
• DOI: 10.1002/ana.10111
• EISSN: 1531-8249
• ISSN: 0364-5134
• Language: English
• Keywords: Brain Diseases; Aged; Magnetic Resonance Imaging; Aged, 80 and over; Random Allocation; Female; Cross-Sectional Studies; Risk Factors; Brain; Humans; Cerebral Infarction; Homocysteine; Odds Ratio; Middle Aged; Male