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Journal article

Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis

Abstract:

Objectives Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate anti-NGF antibodies for reversal of pain behaviour in a surgical model of OA.

Methods Virus-like particles were derived from the cucumber mosaic virus (CuMV) and coupled to expressed recombinant NGF to create the vaccine. 10-week-old male m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1136/annrheumdis-2018-214489

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Green Templeton College
ORCID:
0000-0001-7949-8654
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
CCMP
ORCID:
0000-0003-1092-8155
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Volume:
78
Issue:
5
Pages:
672-675
Publication date:
2019-03-12
Acceptance date:
2019-01-26
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Pubs id:
pubs:977365
URN:
uri:6d26d61d-8c7c-4fd0-b374-2e16fc2d7844
UUID:
uuid:6d26d61d-8c7c-4fd0-b374-2e16fc2d7844
Local pid:
pubs:977365

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