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Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes.

Abstract:

AIMS/HYPOTHESIS: Ca(2+)/calmodulin-dependent protein kinase II, is expressed in the pancreatic beta cells and is activated by glucose and other secretagogues in a manner correlating with insulin secretion. The activation of Ca(2+)/calmodulin-dependent protein kinase II mediates some of the actions of Ca(2+) on the exocytosis of insulin. We therefore investigated the gene encoding the gamma isoform ( CAMK2G) which has been shown to be expressed in human beta cells as a candidate gene for Type ...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-002-0779-8

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
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Journal:
Diabetologia
Volume:
45
Issue:
4
Pages:
580-583
Publication date:
2002-04-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:6d229a2b-340e-4932-8486-4aee4b1b86d5
Source identifiers:
16261
Local pid:
pubs:16261

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