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The 3-phosphoinositide–dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites

Abstract:

Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however, are only partially understood, and PfPKAc function has not been investigated in gametocytes, the sexual blood stage forms that are essential for malaria transmission. By studying a conditional PfPKAc knockdown (cKD) mutant, we confirm the esse...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.3001483

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Publisher:
Public Library of Science
Journal:
PLoS Biology More from this journal
Volume:
19
Issue:
12
Article number:
e3001483
Publication date:
2021-12-08
Acceptance date:
2021-11-12
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Keywords:
Pubs id:
1212381
Local pid:
pubs:1212381
Deposit date:
2021-11-29

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