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Amplification of DNA damage by a γH2AX-targeted radiopharmaceutical

Abstract:

111In-DTPA-anti-γH2AX-Tat, which combines an anti-γH2AX antibody with a cell-penetrating peptide, Tat, and the Auger electron-emitting radioisotope, 111In, targets the DNA damage signalling protein, γH2AX, and has potential as a probe for imaging DNA damage in vivo. The goal of this study was to investigate whether 111In-DTPA-anti-γH2AX-Tat labelled to high specific activity (6MBq/μg) can amplify treatment-related DNA damage for therapeutic gain. Methods: MDA-MB-468 and MDA-MB-231/H2N (231-H2...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
Nuclear Medicine and Biology
Volume:
39
Issue:
8
Pages:
1142-1151
Publication date:
2012-11-01
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
Source identifiers:
359796
Language:
English
Keywords:
Pubs id:
pubs:359796
UUID:
uuid:6d1b4169-edea-4ced-9a67-11d68af6a4eb
Local pid:
pubs:359796
Deposit date:
2013-11-16

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