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Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain.

Abstract:

Catechol-o-methyltransferase (COMT) is important for modulating dopamine levels, prefrontal cortex (PFC) function, and several psychiatric phenotypes. A single COMT mRNA has been described in human brain, which gives rise to membrane-bound (MB)- and soluble (S)-COMT proteins. In addition, we have recently described a novel COMT protein isoform in the human PFC, suggesting that there are more COMT gene products expressed than are currently appreciated. Therefore, we have investigated whether v...

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Publication status:
Published

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Publisher copy:
10.1002/ajmg.b.30539

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume:
144B
Issue:
6
Pages:
834-839
Publication date:
2007-09-01
DOI:
EISSN:
1552-485X
ISSN:
1552-4841
Source identifiers:
98022
Language:
English
Keywords:
Pubs id:
pubs:98022
UUID:
uuid:6d0c4dcd-dcac-4edd-bdba-0a4326aa303a
Local pid:
pubs:98022
Deposit date:
2012-12-19

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