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Achieving operational tolerance in transplantation: How can lessons from the clinic inform research directions?

Abstract:

Since the first solid organ transplant between the Herrick twins in 1954, transplantation immunology has sought to move away from harmful immunosuppressive regimens towards tolerogenic strategies that promote long-term graft survival. This has required a concerted multinational effort with scientists and clinicians working towards a common goal. Reports of immunosuppression-free kidney and liver allograft recipients have provided the proof-of-principle, but intentional generation of tolerance...

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Publisher copy:
10.1111/tri.12081
Journal:
Transplant International More from this journal
Volume:
26
Issue:
6
Pages:
576-589
Publication date:
2013-06-01
DOI:
EISSN:
1432-2277
ISSN:
0934-0874
Language:
English
Keywords:
Pubs id:
pubs:407454
UUID:
uuid:6d0bab2d-0229-41f4-801f-c966f66591e6
Local pid:
pubs:407454
Source identifiers:
407454
Deposit date:
2013-11-17

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