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Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat

Abstract:

The development of pathologies during pregnancy, including pre-eclampsia, hypertension and fetal growth restriction (FGR), often originates from poor functioning of the placenta. In vivo models of maternal stressors, such as nutrient deficiency, and placental insufficiency often focus on inadequate growth of the fetus and placenta in late gestation. These studies rarely investigate the origins of poor placental formation in early gestation, including those affecting the pre-implantation embry...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.172205

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
146
Issue:
2019
Article number:
dev172205
Publication date:
2019-06-10
Acceptance date:
2019-04-18
DOI:
EISSN:
1477-9129
ISSN:
1950-1991
Language:
English
Keywords:
Pubs id:
pubs:1010635
UUID:
uuid:6d065d02-63df-4070-bb33-5f65e89becdd
Local pid:
pubs:1010635
Source identifiers:
1010635
Deposit date:
2019-06-10

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