Journal article
Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells
- Abstract:
-
Planar supported lipid bilayers (PSLBs) presenting T cell receptor (TCR) ligands and ICAM-1 induce budding of extracellular microvesicles enriched in functional TCR, defined here as synaptic ectosomes (SE), from helper T cells. SE bind peptide-MHC directly exporting TCR into the synaptic cleft, but incorporation of other effectors is unknown. Here, we utilized bead supported lipid bilayers (BSLB) to capture SE from single immunological synapses (IS), determined SE composition by immunofluores...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Kennedy Institute of Rheumatology Trust
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife
- Volume:
- 8
- Article number:
- e47528
- Publication date:
- 2019-08-30
- Acceptance date:
- 2019-08-28
- DOI:
- EISSN:
-
2050-084X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1048548
- UUID:
-
uuid:6cf62516-0e90-4726-a736-a8b0c6301127
- Local pid:
- pubs:1048548
- Source identifiers:
-
1048548
- Deposit date:
- 2019-09-02
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