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Journal article

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.

Abstract:

Adaptive immune responses are driven by interactions between T cell antigen receptors (TCRs) and complexes of peptide antigens (p) bound to Major Histocompatibility Complex proteins (MHC) on the surface of antigen-presenting cells. Many experiments support the hypothesis that T cell response is quantitatively and qualitatively dependent on the so-called strength of TCR/pMHC association. Most available data are correlations between binding parameters measured in solution (three-dimensional) an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2011.11.4018

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Biophysical journal Journal website
Volume:
102
Issue:
2
Pages:
248-257
Publication date:
2012-01-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
254516
Language:
English
Keywords:
Subjects:
UUID:
uuid:6cf3c3b9-e70f-4264-9328-007ac89812a1
Local pid:
pubs:254516
Deposit date:
2012-12-19

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