Conference item : Abstract
Activation of SMAD2 upon compressive load occurs exclusively in regions of cartilage where matrix stiffness is relatively low
- Abstract:
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Mechanical force is an important factor affecting the health of articular cartilage and consequently the function of the joint. Work from our lab has identified an important mechanotransducing role for the pericellular matrix (PCM) of cartilage; sequesteringregulatory molecules such as fibroblastic growth factor 2 (FGF2), latent transforming growth factor beta (TGFβ) and connective tissue growth factor (CTGF). In unloaded cartilage these molecules are held back from the cell surface, but upo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 82.4KB)
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- Publisher copy:
- 10.1016/j.joca.2016.01.297
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Host title:
- Osteoarthritis and Cartilige
- Journal:
- Osteoarthritis and Cartilage Journal website
- Volume:
- 24
- Issue:
- S16
- Pages:
- S152
- Publication date:
- 2016-03-01
- DOI:
- ISSN:
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1063-4584
Item Description
- Keywords:
- Subtype:
- Abstract
- Pubs id:
-
pubs:619697
- UUID:
-
uuid:6cf21975-0555-4d10-b4b4-1e8dfae50b44
- Local pid:
- pubs:619697
- Source identifiers:
-
619697
- Deposit date:
- 2016-05-20
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Published by Elsevier Ltd. This paper was presented at the 2016 OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis, Amsterdam, Netherlands, March-April 2016. This is the accepted manuscript version of the abstract, available under a Creative Commons, Attribution, Non-Commercial, Non-Derivative license. The final version is available online from Elsevier at: https://doi.org/10.1016/j.joca.2016.01.297
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