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The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours.

Abstract:

DEC1, also known as SHARP-2 or Stra13, is an important molecule in embryonic differentiation and has recently been identified to be strongly inducible by hypoxia. Its distribution in normal human tissues and most tumour types is unknown. In the present study, a polyclonal antiserum to a 10-amino acid peptide from DEC1 has been raised. Using this antiserum, DEC1 was shown to be widely expressed in most normal human tissues, but usually only in a proportion of cells and typically with a nuclear...

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Publication status:
Published

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Publisher copy:
10.1002/path.1585

Authors


Wykoff, CC More by this author
Watson, PH More by this author
Gatter, KC More by this author
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Journal:
The Journal of pathology
Volume:
203
Issue:
3
Pages:
808-813
Publication date:
2004-07-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:6ced6dc9-d6e7-4d8d-8e30-d5e49a32549a
Source identifiers:
119308
Local pid:
pubs:119308

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