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Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25.

Abstract:

The human ovalbumin (ov) serpins are associated with tumorigenesis, inflammation, and protection from autolysis by granule proteinases. Their genes are located at 18q21 or 6p25, falling into two structurally very similar but distinct categories depending on the presence or absence of a particular exon. Analysis of ov-serpin gene structure provides an opportunity to elucidate the mechanisms contributing to the formation of the larger serpin gene superfamily. Here we have identified a new gene ...

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Publication status:
Published

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Publisher copy:
10.1006/geno.1999.6021

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Journal:
Genomics More from this journal
Volume:
62
Issue:
3
Pages:
490-499
Publication date:
1999-12-01
DOI:
EISSN:
1089-8646
ISSN:
0888-7543

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