Conference item
Enhanced viral activity in tumors using focused ultrasound and microbubbles-A long term study.
- Abstract:
-
Oncolytic viruses target and kill cancer cells and self-amplify through replication. However, viral therapy in vivo is limited by insufficient systemic delivery. Here, focused ultrasound (FUS) was used in conjunction with microbubbles to produce cavitation and enhance tumor viral delivery. Human breast cancer cells (ZR75.1) were injected subcutaneously in mice (n = 8), which grew to a tumor volume of at least 30 mm(3). The tumors were then exposed to FUS (frequency: 0.5 MHz, pulse duration: 5...
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Bibliographic Details
- Host title:
- J Acoust Soc Am
- Volume:
- 130
- Issue:
- 4
- Pages:
- 2502
- Publication date:
- 2011-10-01
- Event location:
- United States
- DOI:
- EISSN:
-
1520-8524
- ISSN:
-
0001-4966
Item Description
- Pubs id:
-
pubs:186615
- UUID:
-
uuid:6cea1ca9-13f0-49e3-b29a-ddb6ba31a5b2
- Local pid:
- pubs:186615
- Source identifiers:
-
186615
- Deposit date:
- 2012-12-20
Terms of use
- Copyright date:
- 2011
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