Journal article : Comment
Notum deacylates octanoylated ghrelin
- Abstract:
-
Objectives The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signalling. Whether Notum also deacylates ghrelin has not been determined.
Methods We used mass-spectrometry to assay ghrelin deacylation by Notum and co-crystallisa... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Molecular Metabolism Journal website
- Volume:
- 49
- Article number:
- 101201
- Publication date:
- 2021-02-27
- Acceptance date:
- 2021-02-24
- DOI:
- EISSN:
-
2212-8778
Item Description
- Language:
- English
- Keywords:
- Subtype:
- Comment
- Pubs id:
-
1163711
- Local pid:
- pubs:1163711
- Deposit date:
- 2021-02-27
Terms of use
- Copyright holder:
- Y Zhao et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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