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Notum deacylates octanoylated ghrelin

Abstract:
Objectives The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signalling. Whether Notum also deacylates ghrelin has not been determined.
Methods We used mass-spectrometry to assay ghrelin deacylation by Notum and co-crystallisa... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molmet.2021.101201

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Publisher:
Elsevier
Journal:
Molecular Metabolism More from this journal
Volume:
49
Article number:
101201
Publication date:
2021-02-27
Acceptance date:
2021-02-24
DOI:
EISSN:
2212-8778
Language:
English
Keywords:
Subtype:
Comment
Pubs id:
1163711
Local pid:
pubs:1163711
Deposit date:
2021-02-27

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