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Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

Abstract:

The 39-42 amino acid long, amphipathic amyloid-beta peptide (Abeta) is one of the key components involved in Alzheimer's disease (AD). In the neuropathology of AD, Abeta presumably exerts its neurotoxic action via interactions with neuronal membranes. In our studies a combination of 31P MAS NMR (magic angle spinning nuclear magnetic resonance) and CD (circular dichroism) spectroscopy suggest fundamental differences in the functional organization of supramolecular Abeta(1-40) membrane assembli...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2003.11.046

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Journal of molecular biology More from this journal
Volume:
335
Issue:
4
Pages:
1039-1049
Publication date:
2004-01-01
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Language:
English
Keywords:
Pubs id:
pubs:100686
UUID:
uuid:6ce441d5-b080-4087-be27-f98ffadd215c
Local pid:
pubs:100686
Source identifiers:
100686
Deposit date:
2012-12-19

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