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Journal article

The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.

Abstract:

BACKGROUND: Benign prostatic hyperplasia (BPH) is characterized by a proportional increase in the size of the stromal compartment of the gland, involving alterations to extracellular matrix (ECM) components. Some of these changes have been associated with the activity and expression of transforming growth factor beta1 (TGFbeta1). Versican (chondroitin sulphate proteoglycan-2) is overexpressed in BPH and prostate cancer and potentially contributes to disease pathology. A sub-group of the ADAM...

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Publication status:
Published

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Publisher copy:
10.1002/pros.20182

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Journal:
Prostate
Volume:
63
Issue:
3
Pages:
269-275
Publication date:
2005-05-01
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
Source identifiers:
120728

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