Journal article
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome.
- Abstract:
-
GATA-1 is the founding member of a transcription factor family that regulates growth and maturation of a diverse set of tissues. GATA-1 is expressed primarily in hematopoietic cells and is essential for proper development of erythroid cells, megakaryocytes, eosinophils, and mast cells. Although loss of GATA-1 leads to differentiation arrest and apoptosis of erythroid progenitors, absence of GATA-1 promotes accumulation of immature megakaryocytes. Recently, we and others have reported that mut...
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- Publication status:
- Published
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- Publisher copy:
- 10.1182/blood-2003-05-1556
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Authors
Bibliographic Details
- Journal:
- Blood
- Volume:
- 103
- Issue:
- 2
- Pages:
- 399-406
- Publication date:
- 2004-01-01
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
38957
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:38957
- UUID:
-
uuid:6ccd7dd9-5014-40a9-a478-7e3b32c6040d
- Local pid:
- pubs:38957
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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