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Exploiting the carboxylate chemical shift to resolve degenerate resonances in spectra of 13C-labelled glycosaminoglycans.

Abstract:

Glycosaminoglycans (GAG) are important vertebrate extracellular matrix polysaccharides that comprise repeated units of an acidic and an N-acetylated sugar. The constituent acidic sugars are central to their biological functions, but have been largely inaccessible to NMR because the (1)H resonances overlap with those from other residues. Here, pulse sequences that address this failure are developed using (13)C-enriched oligosaccharides of the glycosaminoglycan, hyaluronan, as model systems. Tw...

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Publisher copy:
10.1002/mrc.1620
Journal:
Magnetic resonance in chemistry : MRC More from this journal
Volume:
43
Issue:
10
Pages:
805-815
Publication date:
2005-10-01
DOI:
EISSN:
1097-458X
ISSN:
0749-1581
Language:
English
Keywords:
Pubs id:
pubs:246406
UUID:
uuid:6ccb4460-f75c-4737-9c89-292cd75fc592
Local pid:
pubs:246406
Source identifiers:
246406
Deposit date:
2013-11-16

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