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Metabolic enzymes enjoying new partnerships as RNA-binding proteins

Abstract:

In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, or malignant transformation are now known to involve ‘metabolic remodeling’ with profound changes in the expression of many metabolic enzyme genes. This review focuses on the recent identification of RNA-binding activity of numerous metabolic enzymes. We dis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tem.2015.09.012

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
National Health and Medical Research Council of Australia
Funding agency for:
Hentze, M
Preiss, T
Grant:
1045417
1045417
More from this funder
Name:
Virtual Liver Network of the German Ministry for Science and Education
Funding agency for:
Hentze, M
Grant:
1045417
More from this funder
Name:
European Research Council
Funding agency for:
Hentze, M
Grant:
1045417
More from this funder
Name:
Medical Research Council
Funding agency for:
Castello, A
Grant:
MR/L019434/1
Publisher:
Cell Press
Journal:
Trends in Endocrinology and Metabolism More from this journal
Volume:
26
Issue:
12
Pages:
746-757
Publication date:
2015-10-01
DOI:
ISSN:
1043-2760
Pubs id:
pubs:581718
UUID:
uuid:6cc29afe-152b-419a-8231-8be41a1a3e77
Local pid:
pubs:581718
Source identifiers:
581718
Deposit date:
2016-01-13

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