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Delaying antimalarial drug resistance with combination chemotherapy.

Abstract:

Resistance to antimalarial drugs arises when spontaneously occurring mutants with gene mutations or amplifications which confer reduced drug susceptibility are selected, and are then transmitted. Simultaneous use of two or more antimalarials with different modes of action and which therefore do not share the same resistance mechanisms will reduce the chance of selection, because the chance of a resistant mutant surviving is the product of the parasite mutation rates for the individual drugs, ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
Journal:
Parassitologia
Volume:
41
Issue:
1-3
Pages:
301-308
Publication date:
1999-09-05
ISSN:
0048-2951
URN:
uuid:6cbfbc21-f925-4c9c-889e-63554f050cde
Source identifiers:
95501
Local pid:
pubs:95501

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