Journal article
Delaying antimalarial drug resistance with combination chemotherapy.
- Abstract:
-
Resistance to antimalarial drugs arises when spontaneously occurring mutants with gene mutations or amplifications which confer reduced drug susceptibility are selected, and are then transmitted. Simultaneous use of two or more antimalarials with different modes of action and which therefore do not share the same resistance mechanisms will reduce the chance of selection, because the chance of a resistant mutant surviving is the product of the parasite mutation rates for the individual drugs, ...
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Bibliographic Details
- Journal:
- Parassitologia
- Volume:
- 41
- Issue:
- 1-3
- Pages:
- 301-308
- Publication date:
- 1999-09-01
- ISSN:
-
0048-2951
- Source identifiers:
-
95501
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:95501
- UUID:
-
uuid:6cbfbc21-f925-4c9c-889e-63554f050cde
- Local pid:
- pubs:95501
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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