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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial

Abstract:
Background Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative da... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-018-2600-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Green Templeton College
Role:
Author
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Name:
National Health and Medical Research Council
Grant:
1088738
Publisher:
BioMed Central
Journal:
Trials More from this journal
Volume:
19
Issue:
1
Article number:
250
Publication date:
2018-04-24
Acceptance date:
2018-03-19
DOI:
ISSN:
1745-6215
Pmid:
29690924
Language:
English
Keywords:
Pubs id:
pubs:846205
UUID:
uuid:6cbbce1d-1bdb-47e4-847a-83214872027c
Local pid:
pubs:846205
Source identifiers:
846205
Deposit date:
2018-05-09

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