Gene x gene interactions in genome wide association studies

Thesis

Genome wide association studies (GWAS) have revolutionized our approach to mapping genetic determinants of complex human diseases. However, even with success from recent studies, we have typically been able to explain only a fraction of the trait heritability. GWAS are typically analysed by testing for the marginal effects of single variants. Consequently, it has been suggested that gene-gene interactions might contribute to the missing heritability of complex diseases.

GWAS incorpo...

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Authors: Bhattacharya, K

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Bioinformatics; Computation; Rheumatoid arthritis; Statistics; Hypertension; Diabetes; WTCCC; Epistasis; Inflammatory bowel disease; Coronary Heart Disease; Genetics; Intrapid; Obesity; Crohn's disease; Interaction
• Subjects: Statistics (see also social sciences); Bioinformatics (technology); Bioinformatics (life sciences); Mathematical genetics and bioinformatics (statistics); Mathematical biology; Genetics (life sciences); Mathematics