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Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.

Abstract:

OBJECTIVE: Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage. METHODS: Aggrecan catabolism was induced by interleukin-1alpha (IL-1alpha) in normal human articular cartilage and assessed by measuring the release of glycosaminoglycan (GAG) and aggrecanase-dependent fragments by Western blotting with antibodies a...

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Publication status:
Published

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Publisher copy:
10.1002/art.24025

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Arthritis and rheumatism
Volume:
58
Issue:
11
Pages:
3498-3509
Publication date:
2008-11-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:6cb73c29-3053-4a93-bb4d-4c7ecdcfc263
Source identifiers:
226635
Local pid:
pubs:226635

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