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Ethyl 2-(2,3-dihyroxybenzamido) ccetate induces hypoxia induced factor-related metabolic changes in cardiosphere-derived cells for myocardial infarction therapy

Abstract:

Hypoxia induced factor (HIF) transcriptional complex is a potent inducer of cytokines that enhances therapeutic potential of stem cell. Here, ethyl 2-(2,3-dihyroxybenzamido) acetate (EDBA) was used to stabilize HIF-α in cardiosphere-derived cells (CDCs) with the aim of enhancing their therapeutic potential for myocardial infarction. In this study, neonatal Sprague Dawley (SD) rat hearts (n=12) were excised, minced and cultured to generate explant-derived...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Schofield, C
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Funding agency for:
Schofield, C
Malaysian Ministry of Higher Education More from this funder
Publisher:
Universiti Sains Malaysia Publisher's website
Journal:
Health and the Environment Journal Journal website
Volume:
7
Issue:
2
Pages:
77-95
Publication date:
2016-11-05
Acceptance date:
2016-11-21
ISSN:
2180-1126
Pubs id:
pubs:664353
URN:
uri:6cb6b24a-5d5a-49b8-9f2f-54dcd095b0a9
UUID:
uuid:6cb6b24a-5d5a-49b8-9f2f-54dcd095b0a9
Local pid:
pubs:664353

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