Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy.
RATIONALE: Glutathione (GSH) is a key scavenger for cellular free radicals, and patients with bipolar disorder may have lowered GSH levels in plasma and in post-mortem brain tissue. OBJECTIVES: The objective of the current study was to use magnetic resonance spectroscopy (MRS) to measure cortical GSH levels in young people with bipolar disorder to determine if lowered GSH might be a useful biomarker of vulnerability to the illness. METHODS: We studied 13 patients with DSM-IV bipolar disorder ...Expand abstract
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