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Journal article

Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance

Abstract:

Solid tumours have oxygen gradients and areas of near and almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors and were altered consistently in six CRC cell lines (colon cancer: DLD-1, HCT116 and HT29; rectal cancer: HT55, SW837 and VACO4S) maintained in hypoxia (1 and 0.2% oxygen) compared with normoxia (20.9%). CRC cell lines also showed altered amino acid metabolism in hypoxia and hypoxia-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/hmg/ddx059

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-7980-7151
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
26
Issue:
8
Pages:
1552–1564
Publication date:
2017-02-16
Acceptance date:
2017-02-13
DOI:
ISSN:
0964-6906 and 1460-2083
Pubs id:
pubs:681423
URN:
uri:6caeb38e-02bd-41f5-beba-ed00e1f5f20a
UUID:
uuid:6caeb38e-02bd-41f5-beba-ed00e1f5f20a
Local pid:
pubs:681423

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