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Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to chronic bone marrow failure: a meta-analysis and systematic review

Abstract:

BACKGROUND: People with thrombocytopenia due to bone marrow failure are vulnerable to bleeding. Platelet transfusions have limited efficacy in this setting and alternative agents that could replace, or reduce platelet transfusion, and are effective at reducing bleeding are needed. OBJECTIVES: To compare the relative efficacy of different interventions for patients with thrombocytopenia due to chronic bone marrow failure and to derive a hierarchy of potential alternative treatments to platelet...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/14651858.CD012055.pub2

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Grant:
NIHRCochraneProgrammeGrant-Safe
AppropriateUseofBloodComponents
Publisher:
John Wiley & Sons, Ltd Publisher's website
Journal:
Cochrane Database of Systematic Reviews Journal website
Issue:
10
Article number:
CD012055
Publication date:
2016-10-31
DOI:
ISSN:
1469-493X
Source identifiers:
656460
Language:
English
Keywords:
Pubs id:
pubs:656460
UUID:
uuid:6cab24ad-847c-41f3-9d2a-b61d33b88a0c
Local pid:
pubs:656460
Deposit date:
2016-11-18

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