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Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis

Abstract:

STUDY QUESTION
Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis?

SUMMARY ANSWER
GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated prote...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/humrep/dex024

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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More from this funder
Grant:
241944, 339462, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496610, 496739, 552485,552498
More from this funder
Grant:
WT084766/Z/08/Z, 076113, 085475, WT098017
Publisher:
Oxford University Press Publisher's website
Journal:
Human Reproduction Journal website
Volume:
32
Issue:
4
Pages:
780-793
Publication date:
2017-02-09
Acceptance date:
2017-01-24
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
Source identifiers:
687078
Language:
English
Keywords:
Pubs id:
pubs:687078
UUID:
uuid:6ca6a935-6955-4a48-9609-790df287c69b
Local pid:
pubs:687078
Deposit date:
2017-05-02

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