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Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis

Abstract:

STUDY QUESTION
Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis?

SUMMARY ANSWER
GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated prote...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/humrep/dex024

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Nyholt, DR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics & Gynaecology
Missmer, SA More by this author
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Grant:
WT084766/Z/08/Z, 076113, 085475, WT098017
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Grant:
241944, 339462, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496610, 496739, 552485,552498
Publisher:
Oxford University Press Publisher's website
Journal:
Human Reproduction Journal website
Volume:
32
Issue:
4
Pages:
780-793
Publication date:
2017-02-09
Acceptance date:
2017-01-24
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
Pubs id:
pubs:687078
URN:
uri:6ca6a935-6955-4a48-9609-790df287c69b
UUID:
uuid:6ca6a935-6955-4a48-9609-790df287c69b
Local pid:
pubs:687078

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