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Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.

Abstract:

AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions. METHODS: Twenty-six children with severe malaria and convulsions lasting > or =5 min were studied. Fifteen children were given a single dose (0.1 mg kg(-1)) of i.v. LZP and 11 received a similar i.m. dose. Blood samples were collected over 72 h for determination of plasma LZP concentrations. Plasma LZP concentration-...

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Publication status:
Published

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Journal:
British journal of clinical pharmacology More from this journal
Volume:
65
Issue:
1
Pages:
12-21
Publication date:
2008-01-01
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
Language:
English
Keywords:
Pubs id:
pubs:185649
UUID:
uuid:6ca480fa-3d36-4673-942a-5742e1a95f98
Local pid:
pubs:185649
Source identifiers:
185649
Deposit date:
2012-12-19

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