Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.

Journal article

AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions. METHODS: Twenty-six children with severe malaria and convulsions lasting > or =5 min were studied. Fifteen children were given a single dose (0.1 mg kg(-1)) of i.v. LZP and 11 received a similar i.m. dose. Blood samples were collected over 72 h for determination of plasma LZP concentrations. Plasma LZP concentration-...

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Authors: Muchohi, SN; Obiero, K; Newton, C; Ogutu, B; Edwards, G

• Publication status: Published
• Journal: British journal of clinical pharmacology
• Volume: 65
• Issue: 1
• Pages: 12-21
• Publication date: 2008-01-01
• DOI: 10.1111/j.1365-2125.2007.02966.x
• EISSN: 1365-2125
• ISSN: 0306-5251
• Language: English
• Keywords: Injections, Intramuscular; Statistics as Topic; Seizures; Rural Health; Lorazepam; Child; Child, Preschool; Malaria; Female; Injections, Intravenous; Infant; Male; Humans; Anticonvulsants; Africa