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Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

Abstract:

Human immunodeficiency virus 1 (HIV-1) is a life-threatening pathogen that still lacks a curative therapy or vaccine. Despite the reduction in AIDS-related deaths achieved by current antiretroviral therapies, drawbacks including drug resistance and the failure to eradicate infection highlight the need to identify new pathways to target the infection. Circadian rhythms are endogenous 24-h oscillations which regulate physiological processes including immune responses to infection, and there is ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-020-70170-3

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Institution:
University of Oxford
Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author
More by this author
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Name:
Wellcome Trust
Grant:
200838/Z/16/Z
More from this funder
Name:
Medical Research Council
Grant:
DJAA.RRAK21050
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
10
Article number:
13271
Publication date:
2020-08-06
Acceptance date:
2020-07-07
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
1119104
Local pid:
pubs:1119104
Deposit date:
2020-07-16

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