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Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: In vivo and in vitro evidence

Abstract:

Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration. Objective To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes. Methods Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and active mammalian/ mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary ...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Publisher:
BMJ Publishing Group
Journal:
Annals of the Rheumatic Diseases
Volume:
73
Issue:
7
Pages:
1405-1413
Publication date:
2014-01-01
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:6c9f5aae-2348-4004-8a5b-b3174831216e
Source identifiers:
471688
Local pid:
pubs:471688
Language:
English

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