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Journal article

CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.

Abstract:
Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.
Publication status:
Published

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Publisher copy:
10.1080/15257770701533958

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Nucleosides, nucleotides and nucleic acids More from this journal
Volume:
26
Issue:
10-12
Pages:
1363-1367
Publication date:
2007-01-01
DOI:
EISSN:
1532-2335
ISSN:
1525-7770
Language:
English
Keywords:
Pubs id:
pubs:400021
UUID:
uuid:6c9ee907-766d-46aa-ae74-300bcc8aa845
Local pid:
pubs:400021
Source identifiers:
400021
Deposit date:
2013-11-16

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