- Abstract:
-
Background
Autosomal dominant optic atrophy (ADOA) is usually caused by mutations in the essential gene, OPA1. This encodes a ubiquitous protein involved in mitochondrial dynamics, hence tissue specificity is not understood. Dysregulated mitophagy (mitochondria recycling) is implicated in ADOA, being increased in OPA1 patient fibroblasts. Furthermore, autophagy may be increased in retinal ganglion cells (RGCs) of the OPA1Q285STOP mouse model.
Aims
We developed a m...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.2MB)
-
- Publisher copy:
- 10.3389/fcell.2018.00103
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Cell and Developmental Biology Journal website
- Volume:
- 6
- Issue:
- SEP
- Pages:
- 103
- Publication date:
- 2018-09-19
- Acceptance date:
- 2018-08-13
- DOI:
- EISSN:
-
2296-634X
- Pubs id:
-
pubs:923640
- URN:
-
uri:6c9e1121-02b2-42e2-a206-2ccd3ef3f0d1
- UUID:
-
uuid:6c9e1121-02b2-42e2-a206-2ccd3ef3f0d1
- Local pid:
- pubs:923640
- Language:
- English
- Keywords:
- Copyright holder:
- Diot et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Diot, Agnew, Sanderson, Liao, Carver, Neves, Gupta, Guo,Waters, Seto, Daniels, Dombi, Lodge,Morten,Williams, Enver, Iborra, Votruba and Poulton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Journal article
Validating the RedMIT/GFP-LC3 mouse model by studying mitophagy in autosomal dominant optic atrophy due to the OPA1Q285STOP mutation
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bloodwise
More from this funder
NewLife
More from this funder
Expand funders...
Bibliographic Details
Item Description
Terms of use
If you are the owner of this record, you can report an update to it here: Report update to this record