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Targeting the lncRNA SAMMSON reveals metabolic vulnerability in melanoma

Abstract:
In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 status.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ccell.2016.04.010

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Publisher:
Cell Press Publisher's website
Journal:
Cancer Cell Journal website
Volume:
29
Issue:
5
Pages:
619–621
Publication date:
2016
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:6c97790c-51b6-4653-a285-a1ff95285a8d
Source identifiers:
619465
Local pid:
pubs:619465

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