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Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility.

Abstract:

BACKGROUND: Germline mutations in three subunits of mitochondrial complex II (SDHB, SDHC and SDHD) may be associated with susceptibility to phaeochromocytoma (PC) and/or head and neck paraganglioma (HNPGL). METHODS: To further define the role of SDH subunit mutations in these disorders, we analysed a series of 22 probands with PC and evidence of genetic susceptibility (seven with familial PC only, one with familial PC and HNPGL, 10 sporadic cases with multiple PC and four cases of isolated p...

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Publication status:
Published

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Journal:
Clinical endocrinology More from this journal
Volume:
59
Issue:
6
Pages:
728-733
Publication date:
2003-12-01
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Language:
English
Keywords:
Pubs id:
pubs:138628
UUID:
uuid:6c8e9b7b-cea8-45c2-94c7-5bd459eeff06
Local pid:
pubs:138628
Source identifiers:
138628
Deposit date:
2012-12-19

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