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Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.

Abstract:

BACKGROUND: A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This association has not been investigated in terms of Gag-specific CD4+ T cell responses, nor have clade C HIV-1-specific CD4+ T cell epitopes, likely a vital component of an effective global HIV-1 vaccine, been identified. METHODOLOGY/PRINCIPAL FINDINGS: Intracellular cytokine ...

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10.1371/journal.pone.0005013

Authors


Ramduth, D More by this author
Thobakgale, CF More by this author
Mkhwanazi, NP More by this author
de Pierres, C More by this author
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Journal:
PloS one
Volume:
4
Issue:
4
Pages:
e5013
Publication date:
2009
DOI:
EISSN:
1932-6203
URN:
uuid:6c8802d6-4709-4c5d-8f4b-68525bc2a33b
Source identifiers:
191174
Local pid:
pubs:191174

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