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PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

Abstract:

p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show the existence of a proapoptotic autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia (PML) tumor suppressor gene. We demonstrate that PML is a direct transcriptional target of p73/YAP, and we show tha...

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Publication status:
Published

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Journal:
Molecular cell More from this journal
Volume:
32
Issue:
6
Pages:
803-814
Publication date:
2008-12-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765

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