Journal article : Letter
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
- Abstract:
-
Biosynthesis of glycogen, the essential glucose (and hence energy) storage molecule in humans, animals and fungi1, is initiated by the glycosyltransferase enzyme, glycogenin (GYG). Deficiencies in glycogen formation cause neurodegenerative and metabolic disease2,3,4, and mouse knockout5 and inherited human mutations6 of GYG impair glycogen synthesis. GYG acts as a ‘seed core’ for the formation of the glycogen particle by catalysing its own stepwise autoglucosylation to form a covalently bound...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 4.7MB)
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- Publisher copy:
- 10.1038/s41586-018-0644-7
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Authors
Funding
+ European Union
More from this funder
Funding agency for:
Davis, B
Grant:
Wolfson Research Merit Award
+ Royal Society
More from this funder
Funding agency for:
Davis, B
Grant:
Wolfson Research Merit Award
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 563
- Issue:
- 7730
- Pages:
- 235-240
- Publication date:
- 2018-10-24
- Acceptance date:
- 2018-08-31
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
- Pmid:
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30356213
- Source identifiers:
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935186
Item Description
- Language:
- English
- Subtype:
- Letter
- Pubs id:
-
pubs:935186
- UUID:
-
uuid:6c7ed216-b260-4be5-9830-78be4c8f97cf
- Local pid:
- pubs:935186
- Deposit date:
- 2018-11-13
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Springer Nature Limited. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41586-018-0644-7
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