Journal article icon

Journal article

Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis

Subtitle:
Letter
Abstract:

Biosynthesis of glycogen, the essential glucose (and hence energy) storage molecule in humans, animals and fungi1, is initiated by the glycosyltransferase enzyme, glycogenin (GYG). Deficiencies in glycogen formation cause neurodegenerative and metabolic disease2,3,4, and mouse knockout5 and inherited human mutations6 of GYG impair glycogen synthesis. GYG acts as a ‘seed core’ for the formation of the glycogen particle by catalysing its own stepwise autoglucosylation to form a covalently bound...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-018-0644-7

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Davis, BG
More from this funder
Funding agency for:
Davis, BG
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
563
Issue:
7730
Pages:
235-240
Publication date:
2018-10-24
Acceptance date:
2018-08-31
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:935186
URN:
uri:6c7ed216-b260-4be5-9830-78be4c8f97cf
UUID:
uuid:6c7ed216-b260-4be5-9830-78be4c8f97cf
Local pid:
pubs:935186
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP