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Journal article : Letter

Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis

Abstract:

Biosynthesis of glycogen, the essential glucose (and hence energy) storage molecule in humans, animals and fungi1, is initiated by the glycosyltransferase enzyme, glycogenin (GYG). Deficiencies in glycogen formation cause neurodegenerative and metabolic disease2,3,4, and mouse knockout5 and inherited human mutations6 of GYG impair glycogen synthesis. GYG acts as a ‘seed core’ for the formation of the glycogen particle by catalysing its own stepwise autoglucosylation to form a covalently bound...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-018-0644-7

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
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Funding agency for:
Davis, B
Grant:
Wolfson Research Merit Award
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Funding agency for:
Davis, B
Grant:
Wolfson Research Merit Award
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
563
Issue:
7730
Pages:
235-240
Publication date:
2018-10-24
Acceptance date:
2018-08-31
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
30356213
Source identifiers:
935186
Language:
English
Subtype:
Letter
Pubs id:
pubs:935186
UUID:
uuid:6c7ed216-b260-4be5-9830-78be4c8f97cf
Local pid:
pubs:935186
Deposit date:
2018-11-13

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