- Subtitle:
- Letter
- Abstract:
-
Biosynthesis of glycogen, the essential glucose (and hence energy) storage molecule in humans, animals and fungi1, is initiated by the glycosyltransferase enzyme, glycogenin (GYG). Deficiencies in glycogen formation cause neurodegenerative and metabolic disease2,3,4, and mouse knockout5 and inherited human mutations6 of GYG impair glycogen synthesis. GYG acts as a ‘seed core’ for the formation of the glycogen particle by catalysing its own stepwise autoglucosylation to form a covalently bound...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 4.7MB)
-
- Publisher copy:
- 10.1038/s41586-018-0644-7
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 563
- Issue:
- 7730
- Pages:
- 235-240
- Publication date:
- 2018-10-24
- Acceptance date:
- 2018-08-31
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- Pubs id:
-
pubs:935186
- URN:
-
uri:6c7ed216-b260-4be5-9830-78be4c8f97cf
- UUID:
-
uuid:6c7ed216-b260-4be5-9830-78be4c8f97cf
- Local pid:
- pubs:935186
- Language:
- English
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Springer Nature Limited. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41586-018-0644-7
Journal article
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
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