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Arginine methylation controls growth regulation by E2F-1

Abstract:

E2F transcription factors are implicated in diverse cellular functions. The founding member, E2F-1, is endowed with contradictory activities, being able to promote cell-cycle progression and induce apoptosis. However, the mechanisms that underlie the opposing outcomes of E2F-1 activation remain largely unknown. We show here that E2F-1 is directly methylated by PRMT5 (protein arginine methyltransferase 5), and that arginine methylation is responsible for regulating its biochemical and function...

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Publisher copy:
10.1038/emboj.2012.17

Authors


Journal:
EMBO Journal More from this journal
Volume:
31
Issue:
7
Pages:
1785-1797
Publication date:
2012-04-04
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:341377
UUID:
uuid:6c7cba23-0236-45ff-8877-4f895f8fb2f0
Local pid:
pubs:341377
Source identifiers:
341377
Deposit date:
2012-12-19

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