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Artemisinin and derivatives in the treatment of uncomplicated malaria.

Abstract:

Artemisinin and its derivatives are the most rapidly acting antimalarials known to-date and are well-tolerated. All derivatives in use today are produced by semi-synthesis from artemisinin: dihydroartemisinin is the product of the first step; more synthetic steps give rise to artesunate, artemether and arteether which are metabolised back to dihydroartemisinin in the body. Although their residence in the body after oral administration is very short (with half-lives of < 2 hours), they can ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Olliaro, P More by this author
Journal:
Medecine tropicale : revue du Corps de sante colonial
Volume:
58
Issue:
3 Suppl
Pages:
54-56
Publication date:
1998
ISSN:
0025-682X
URN:
uuid:6c78977e-027a-4b70-9172-b2326cd54d87
Source identifiers:
95498
Local pid:
pubs:95498

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