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Journal article

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway.

Abstract:

While recombinant adeno-associated virus (rAAV) vectors promote long-term transgene expression in the lungs and other organs, the goal of correcting chronic inherited lung diseases such as cystic fibrosis with this type of viral gene transfer vector is limited by the requirement of achieving stable potent transgene expression, potentially requiring vector readministration. Here we evaluated the abilities of rAAV type 5/5 (rAAV5/5) vectors based on the genome and capsid of AAV5 to efficiently ...

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Publisher copy:
10.1128/jvi.01010-07

Authors


Journal:
Journal of virology
Volume:
81
Issue:
22
Pages:
12360-12367
Publication date:
2007-11-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
246477
Language:
English
Keywords:
Pubs id:
pubs:246477
UUID:
uuid:6c751d1f-e7cf-40c1-a95e-4d388f7d678e
Local pid:
pubs:246477
Deposit date:
2012-12-19

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