Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data.

Journal article

In dynamic positron emission tomography (PET) neuroimaging studies, where scan durations often exceed 1h, registration of motion-corrupted dynamic PET images is necessary in order to maintain the integrity of the physiological, pharmacological, or biochemical information derived from the tracer kinetic analysis of the scan. In this work, we incorporate a pharmacokinetic model, which is traditionally used to analyse PET data following any registration, into the registration process itself in o...

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Authors: Jiao, J; Searle, G; Tziortzi, A; Salinas, C; Gunn, R

• Publication status: Published
• Journal: NeuroImage
• Volume: 84
• Pages: 225-235
• Publication date: 2014-01-01
• DOI: 10.1016/j.neuroimage.2013.08.031
• EISSN: 1095-9572
• ISSN: 1053-8119
• Language: English
• Keywords: Positron-Emission Tomography; Image Enhancement; Male; Humans; Image Interpretation, Computer-Assisted; Carbon Isotopes; Subtraction Technique; Sensitivity and Specificity; Algorithms; Models, Neurological; Receptors, Dopamine D3; Oxazines; Computer Simulation; Reproducibility of Results; Spatio-Temporal Analysis; Young Adult; Female; Time Factors; Brain; Neuroimaging; Radiopharmaceuticals; Imaging, Three-Dimensional