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Thesis

Characterisation and application of an ebola virus glycoprotein pseudotyped influenza virus (E-S-Flu)

Abstract:

Ebola virus (EBOV) is a single-stranded RNA virus from the Filoviridae family. It is a biosafety level 4 pathogen, and infection causes fatal haemorrhagic fever in humans, yet no approved vaccines or therapeutics are available.

We describe a new EBOV surrogate, E-S-FLU, a single-cycle Influenza virus pseudotyped (coated) with the EBOV glycoprotein (GP). E-S-FLU does not contain any genetic information from EBOV, and encodes enhanced green fluorescence protein as a reporter that rep...

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Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author

Contributors

Role:
Supervisor
RDM Scholarship Program, Townsend-Jeantet Prize Trust, Clarendon Fund More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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